Predictors of Mortality for Patients with COVID-19 Pneumonia Caused by SARS-CoV-2: A Prospective Cohort Study
Identifieur interne : 000378 ( 2020/Analysis ); précédent : 000377; suivant : 000379Predictors of Mortality for Patients with COVID-19 Pneumonia Caused by SARS-CoV-2: A Prospective Cohort Study
Auteurs : Rong-Hui Du [République populaire de Chine] ; Li-Rong Liang [République populaire de Chine] ; Cheng-Qing Yang [République populaire de Chine] ; Wen Wang [République populaire de Chine] ; Tan-Ze Cao [République populaire de Chine] ; Ming Li [République populaire de Chine] ; Guang-Yun Guo [République populaire de Chine] ; Juan Du [République populaire de Chine] ; Chun-Lan Zheng [République populaire de Chine] ; Qi Zhu [République populaire de Chine] ; Ming Hu [République populaire de Chine] ; Xu-Yan Li [République populaire de Chine] ; Peng Peng [République populaire de Chine] ; Huan-Zhong Shi [République populaire de Chine]Source :
- The European Respiratory Journal [ 0903-1936 ] ; 2020.
Abstract
To identify factors associated with the death for patients with COVID-19 pneumonia caused by a novel coronavirus SARS-CoV-2.
All clinical and laboratory parameters were collected prospectively from a cohort of patients with COVID-19 pneumonia who were hospitalised to Wuhan Pulmonary Hospital, Wuhan City, Hubei Province, China, between December 25, 2019 and February 7, 2020. Univariate and multivariate logistic regression was performed to investigate the relationship between each variable and the risk for death of COVID-19 pneumonia patients.
A total of 179 patients with COVID-19 pneumonia (97 male and 82 female) were included in the present prospective study, of whom 21 died. Univariate and multivariate logistic regression analysis revealed that age ≥65 years (odd ratio, 3.765; 95% confidence interval, 1.146‒17.394; p=0.023), preexisting concurrent cardiovascular or cerebrovascular diseases (2.464; 0.755‒8.044; p=0.007), CD3+CD8+ T cells ≤75 cell·μL−1 (3.982; 1.132‒14.006; p<0.001), and cardiac troponin I≥0.05 ng·mL−1 (4.077; 1.166‒14.253; p<0.001) were associated with an increase in risk of mortality of COVID-19 pneumonia. In the sex‒, age‒, and comorbid illness-matched case study, CD3+CD8+ T cells ≤75 cell·μL−1 and cardiac troponin I≥0.05 ng·mL−1 remained to be the predictors for high mortality of COVID-19 pneumonia.
We identified four risk factors, age ≥65 years, preexisting concurrent cardiovascular or cerebrovascular diseases, CD3+CD8+ T cells ≤75 cell·μL−1, and cardiac troponin I≥0.05 ng·mL−1, especially the latter two factors, were predictors for mortality of COVID-19 pneumonia patients.
Url:
DOI: 10.1183/13993003.00524-2020
PubMed: 32269088
PubMed Central: 7144257
Affiliations:
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xml:lang="en" level="a" type="main">Predictors of Mortality for Patients with COVID-19 Pneumonia Caused by SARS-CoV-2: A Prospective Cohort Study</title><author><name sortKey="Du, Rong Hui" sort="Du, Rong Hui" uniqKey="Du R" first="Rong-Hui" last="Du">Rong-Hui Du</name><affiliation wicri:level="3"><nlm:aff id="af1">Department of Respiratory and Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation><affiliation><nlm:aff id="af3">These authors contributed equally</nlm:aff></affiliation></author><author><name sortKey="Liang, Li Rong" sort="Liang, Li Rong" uniqKey="Liang L" first="Li-Rong" last="Liang">Li-Rong Liang</name><affiliation wicri:level="3"><nlm:aff id="af2">Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation><nlm:aff id="af3">These authors contributed equally</nlm:aff></affiliation></author><author><name sortKey="Yang, Cheng Qing" sort="Yang, Cheng Qing" uniqKey="Yang C" first="Cheng-Qing" last="Yang">Cheng-Qing Yang</name><affiliation wicri:level="3"><nlm:aff id="af1">Department of Respiratory and Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation><affiliation><nlm:aff id="af3">These authors contributed equally</nlm:aff></affiliation></author><author><name sortKey="Wang, Wen" sort="Wang, Wen" uniqKey="Wang W" first="Wen" last="Wang">Wen Wang</name><affiliation wicri:level="3"><nlm:aff id="af2">Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation><nlm:aff id="af3">These authors contributed equally</nlm:aff></affiliation></author><author><name sortKey="Cao, Tan Ze" sort="Cao, Tan Ze" uniqKey="Cao T" first="Tan-Ze" last="Cao">Tan-Ze Cao</name><affiliation wicri:level="3"><nlm:aff id="af1">Department of Respiratory and Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Li, Ming" sort="Li, Ming" uniqKey="Li M" first="Ming" last="Li">Ming Li</name><affiliation wicri:level="3"><nlm:aff id="af1">Department of Respiratory and Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Guo, Guang Yun" sort="Guo, Guang Yun" uniqKey="Guo G" first="Guang-Yun" last="Guo">Guang-Yun Guo</name><affiliation wicri:level="3"><nlm:aff id="af1">Department of Respiratory and Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Du, Juan" sort="Du, Juan" uniqKey="Du J" first="Juan" last="Du">Juan Du</name><affiliation wicri:level="3"><nlm:aff id="af1">Department of Respiratory and Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Zheng, Chun Lan" sort="Zheng, Chun Lan" uniqKey="Zheng C" first="Chun-Lan" last="Zheng">Chun-Lan Zheng</name><affiliation wicri:level="3"><nlm:aff id="af1">Department of Respiratory and Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Zhu, Qi" sort="Zhu, Qi" uniqKey="Zhu Q" first="Qi" last="Zhu">Qi Zhu</name><affiliation wicri:level="3"><nlm:aff id="af1">Department of Respiratory and Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Hu, Ming" sort="Hu, Ming" uniqKey="Hu M" first="Ming" last="Hu">Ming Hu</name><affiliation wicri:level="3"><nlm:aff id="af1">Department of Respiratory and Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Li, Xu Yan" sort="Li, Xu Yan" uniqKey="Li X" first="Xu-Yan" last="Li">Xu-Yan Li</name><affiliation wicri:level="3"><nlm:aff id="af2">Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Peng, Peng" sort="Peng, Peng" uniqKey="Peng P" first="Peng" last="Peng">Peng Peng</name><affiliation wicri:level="3"><nlm:aff id="af1">Department of Respiratory and Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Shi, Huan Zhong" sort="Shi, Huan Zhong" uniqKey="Shi H" first="Huan-Zhong" last="Shi">Huan-Zhong Shi</name><affiliation wicri:level="3"><nlm:aff id="af2">Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></analytic><series><title level="j">The European Respiratory Journal</title><idno type="ISSN">0903-1936</idno><idno type="eISSN">1399-3003</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>To identify factors associated with the death for patients with COVID-19 pneumonia caused by a novel coronavirus SARS-CoV-2.</p><p>All clinical and laboratory parameters were collected prospectively from a cohort of patients with COVID-19 pneumonia who were hospitalised to Wuhan Pulmonary Hospital, Wuhan City, Hubei Province, China, between December 25, 2019 and February 7, 2020. Univariate and multivariate logistic regression was performed to investigate the relationship between each variable and the risk for death of COVID-19 pneumonia patients.</p><p>A total of 179 patients with COVID-19 pneumonia (97 male and 82 female) were included in the present prospective study, of whom 21 died. Univariate and multivariate logistic regression analysis revealed that age ≥65 years (odd ratio, 3.765; 95% confidence interval, 1.146‒17.394; p=0.023), preexisting concurrent cardiovascular or cerebrovascular diseases (2.464; 0.755‒8.044; p=0.007), CD3<sup>+</sup>CD8<sup>+</sup> T cells ≤75 cell·μL<sup>−1</sup> (3.982; 1.132‒14.006; p<0.001), and cardiac troponin I≥0.05 ng·mL<sup>−1</sup> (4.077; 1.166‒14.253; p<0.001) were associated with an increase in risk of mortality of COVID-19 pneumonia. In the sex‒, age‒, and comorbid illness-matched case study, CD3<sup>+</sup>CD8<sup>+</sup> T cells ≤75 cell·μL<sup>−1</sup> and cardiac troponin I≥0.05 ng·mL<sup>−1</sup> remained to be the predictors for high mortality of COVID-19 pneumonia.</p><p>We identified four risk factors, age ≥65 years, preexisting concurrent cardiovascular or cerebrovascular diseases, CD3<sup>+</sup>CD8<sup>+</sup> T cells ≤75 cell·μL<sup>−1</sup>, and cardiac troponin I≥0.05 ng·mL<sup>−1</sup>, especially the latter two factors, were predictors for mortality of COVID-19 pneumonia patients.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zhu, N" uniqKey="Zhu N">N Zhu</name></author><author><name sortKey="Zhang, D" uniqKey="Zhang D">D Zhang</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Q" uniqKey="Li Q">Q Li</name></author><author><name sortKey="Guan, X" uniqKey="Guan X">X Guan</name></author><author><name sortKey="Wu, P" uniqKey="Wu P">P Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu Jt, Kl" uniqKey="Wu Jt K">KL Wu JT</name></author><author><name sortKey="Leung, Gm" uniqKey="Leung G">GM Leung</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Paules, Ci" uniqKey="Paules C">CI Paules</name></author><author><name sortKey="Marston, Hd" uniqKey="Marston H">HD Marston</name></author><author><name sortKey="Fauci, As" uniqKey="Fauci A">AS Fauci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Z" uniqKey="Wu Z">Z Wu</name></author><author><name sortKey="Mcgoogan, Jm" uniqKey="Mcgoogan J">JM McGoogan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, C" uniqKey="Huang C">C Huang</name></author><author><name sortKey="Wang, Y" 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Perlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhong, Ns" uniqKey="Zhong N">NS Zhong</name></author><author><name sortKey="Zheng, Bj" uniqKey="Zheng B">BJ Zheng</name></author><author><name sortKey="Li, Ym" uniqKey="Li Y">YM Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Christian, Md" uniqKey="Christian M">MD Christian</name></author><author><name sortKey="Poutanen, Sm" uniqKey="Poutanen S">SM Poutanen</name></author><author><name sortKey="Loutfy, Mr" uniqKey="Loutfy M">MR Loutfy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arabi, Ym" uniqKey="Arabi Y">YM Arabi</name></author><author><name sortKey="Balkhy, Hh" uniqKey="Balkhy H">HH Balkhy</name></author><author><name sortKey="Hayden, Fg" uniqKey="Hayden F">FG Hayden</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Hui, Ds" uniqKey="Hui D">DS 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Zhang</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Hubei</li></region><settlement><li>Pékin</li><li>Wuhan</li></settlement></list><tree><country name="République populaire de Chine"><region name="Hubei"><name sortKey="Du, Rong Hui" sort="Du, Rong Hui" uniqKey="Du R" first="Rong-Hui" last="Du">Rong-Hui Du</name></region><name sortKey="Cao, Tan Ze" sort="Cao, Tan Ze" uniqKey="Cao T" first="Tan-Ze" last="Cao">Tan-Ze Cao</name><name sortKey="Du, Juan" sort="Du, Juan" uniqKey="Du J" first="Juan" last="Du">Juan Du</name><name sortKey="Guo, Guang Yun" sort="Guo, Guang Yun" uniqKey="Guo G" first="Guang-Yun" last="Guo">Guang-Yun Guo</name><name sortKey="Hu, Ming" sort="Hu, Ming" uniqKey="Hu M" first="Ming" last="Hu">Ming Hu</name><name sortKey="Li, Ming" sort="Li, Ming" uniqKey="Li M" first="Ming" last="Li">Ming Li</name><name sortKey="Li, Xu Yan" sort="Li, Xu Yan" uniqKey="Li X" first="Xu-Yan" last="Li">Xu-Yan Li</name><name sortKey="Liang, Li Rong" sort="Liang, Li Rong" uniqKey="Liang L" first="Li-Rong" last="Liang">Li-Rong Liang</name><name sortKey="Peng, Peng" sort="Peng, Peng" uniqKey="Peng P" first="Peng" last="Peng">Peng Peng</name><name sortKey="Shi, Huan Zhong" sort="Shi, Huan Zhong" uniqKey="Shi H" first="Huan-Zhong" last="Shi">Huan-Zhong Shi</name><name sortKey="Wang, Wen" sort="Wang, Wen" uniqKey="Wang W" first="Wen" last="Wang">Wen Wang</name><name sortKey="Yang, Cheng Qing" sort="Yang, Cheng Qing" uniqKey="Yang C" first="Cheng-Qing" last="Yang">Cheng-Qing Yang</name><name sortKey="Zheng, Chun Lan" sort="Zheng, Chun Lan" uniqKey="Zheng C" first="Chun-Lan" last="Zheng">Chun-Lan Zheng</name><name sortKey="Zhu, Qi" sort="Zhu, Qi" uniqKey="Zhu Q" first="Qi" last="Zhu">Qi Zhu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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